ASI has been supporting the AMS project since 1995, in a close collaboration with INFN and Italian universities.

More than 60 physicists and engineers from Italian institutes have contributed to the construction and commissioning of AMS-02, to the development of the data analysis and of the ground segment infrastructures. Italian researchers have been responsible for the realisation of four out of the five AMS sub-detectors (namely TOF, Tracker, RICH, ECAL) and for the electronics of the TRD gas control system.  Under the support of ASI, Italian industries developed the thermal control and power distribution systems, the RICH conical mirror and the silicon sensors for the Tracker system.

After the launch and installation of the detector on the ISS in May 2011, ASI has uninterruptedly provided support to the AMS mission, sponsoring the activities of young researchers in the Italian institutes mainly for: operations and monitoring of AMS-02 at the CERN POCC; calibration and verification of the detector performances; scientific data analysis.

Personnel of the ASI Space Science Data Centre (SSDC) and of the ASI Scientific Research Unit (URS) also directly contributes to the detector operations and to the scientific data analysis.

The ASI Space Science Data Centre (SSDC) is a facility established in 2000 that provides data processing, archive and support to space missions. Since the very beginning of its operations, AMS-02 has been included in the multi-mission archive of the centre. A group of INFN staff researchers and post-docs is hosted by the SSDC and is closely collaborating with ASI to provide tools for easy access and use of AMS-02 public data as well as contributing to the AMS-02 operations and data analysis.